The very first thing to try is to use it in your DAW just like you would use any other audio effect (say a reverb or compressor). Intuitively most people think of MIDI Guitar as a virtual instrument (VSTi), but try to think of it as an effect first: It has an audio input (your guitar sound) and audio output (the synth or virtual instrument you load into MIDI Guitar). Used this way as an audio effect it should work with any DAW that supports VST or AudioUnit effects.
After using it as an effect you will probably start to wonder how to get the MIDI output from MIDI guitar into your DAW and into its piano roll. Most DAWs have ways to route the midi output from MIDI Guitar to other places and if not you can always fall back to using the standalone version with a virtual MIDI loop. On Mac OS X, virtual MIDI is built in. On Windows you need to install a virtual midi driver, of which several options are freely available. Please see the “Connect To DAW” option in the MIDI Output section of MIDI Guitar for instructions.
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