I don't use east west and wouldn't be cheeky enough to put their libraries on my computer, a lowly i5 with 8 gig of ram, an ssd and a hdd. I do use Komplete Ultimate 10 with Mixcraft though. It sounds just as good with Mixcraft as it does with my other DAWS. Using it with Mixcraft though means you have an easy to use DAW, with excellent sounds.
I don't have any issues but there are some caveats as you would expect with this setup. As explained above by chibear, you will need a powerful computer if you are going in this direction. Don't ignore this advice or you will be disappointed. On my computer, I only run 3-5 samples from kontakt at any one time, like drums, bass and a keyboard. I then burn to wav file before using another. I use the synths and massive etc and of course all the audio files, but this system has high headroom, I can use my other effects like convolution reverb etc chuck things around without issue.
I also use the Acoustica sounds for other things and sometimes when I have something, I will switch to a Kontakt sample and then burn to wav. However, sometimes mixing Acoustica sounds can result in something good as well.
If I had my samples on ssd then I would use more samples, If I had more ram 16-32, I could definitely load more samples. An i7 might help as well. With Kontakt, it loads sometimes part of the sample and then streams also from disc which is where some gaps in playback can sometimes occur if you are not using ssd's. You run your fingers up the piano and suddenly, there is a delay with one of the notes! With big ssd's, an i7 and 32 gig of ram, I would use all samples most of the time. Bottom line, if you want to do what you are thinking of, you will need an i7 or strong i5, ssd's and 16-32gig of ram, 32 in your case, then you can turn off streaming by Kontakt, you would have a great time.