You should be able to.
I use 6ms setting on my ASIO Focusrite (1st Gen) interface to record guitar. I don't have any problems.
Mixcraft 8 Pro Studio Build 418 (64bit)
AMD Ryzen 8 Core 3.0 GHz,
2TB SSD etc, 40GB RAM,
Windows 10 Professional
Focusrite Scarlett 18i8 (1st Gen, USB2).